Potential chemical compounds can inhibit SARS CoV-2 replication and open the way for the production of anti-SARS CoV-2 therapy.
نویسندگان
چکیده
The genome of severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) has an untranslated region (UTR) that enhances the replication and transcription RNA, subgenomic RNA (sgRNA) which encodes 4 structural proteins are essential for viral replication. host cell SARS CoV-2 expresses important enzyme called TMPRSS2 protease allows virus to invade cell. Peptide conjugated phosphorodiamidate morpholino oligomers (PPMOs) Benzylesulfonyl-d-arginine- proline-4-amidinobenzylamide (BAPA) chemicals have inhibited expression in influenza Peptide also UTR genome, sgRNA porcine reproductive (PRRSV), other locations viruses. combination these can inhibit prevent stop replication, may help production a drug against virus.
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ژورنال
عنوان ژورنال: Microbes and Infectious Diseases (Print)
سال: 2021
ISSN: ['2682-4132', '2682-4140']
DOI: https://doi.org/10.21608/mid.2021.77910.1161